Life Sciences - Research Groups
The understanding of complex biological systems requires the reconstruction of multiscale processes, occurring on multiple spatial and temporal scales.
Our group works at the development of analytical and computational techniques for the description of processes arising in immunology and infectious diseases. In particular, we work on
(i) in-host phenomena at intracellular level (e.g. signaling pathways),
or at cellular level (e.g. interactions of immune cells with infected cells or tumor cells)
(ii) between-hosts dynamics (e.g. pathogen transmission and social dynamics)
and on the coupling of these two scales. This allows, for example, to capture the effects of individual immunity on epidemiological outbreaks in a population, or to study molecular mechanisms and events that influence the dynamic at cellular level (e.g. cell proliferation, death, functionality).
Combining elements of nonlinear and infinite-dimensional dynamics with numerical simulations and optimization, we aim at both qualitative and quantitative understanding of biological phenomena.
Research and Teaching
Our research work on COVID-19
- MV Barbarossa and J Fuhrmann, Compliance with NPIs and possible deleterious effects on mitigation of an epidemic outbreak, preprints (2021) doi: 10.20944/preprints202102.0178.v1
- J Bracher, preprint available , , , , , , , et al., Short-term forecasting of COVID-19 in Germany and Poland during the second wave – a preregistered study, submitted to Nature Comm, in revision (2020)
- MV Barbarossa and J Fuhrmann, Germany's next shutdown - possible scenarios and outcomes, Influenza and Other Respiratory Viruses (2020) DOI: 10.1111/irv.12827
- MV Barbarossa, N Bogya, A Dénes, G Röst, H Vinod Varma, Zs Vizi, Fleeing lockdown and its impact on the size of epidemic outbreaks in the source and target regions - a COVID-19 lesson, preprint on Research Square (2020)
- Fuhrmann, J., Barbarossa, M.V. The significance of case detection ratios for predictions on the outcome of an epidemic - a message from mathematical modelers. Arch Public Health 78, 63 (2020). https://doi.org/10.1186/s13690-020-00445-8
- MV Barbarossa, J Fuhrmann, J Meinke, S Krieg, HV Varma, N Castelletti, and Th Lippert, Modeling the spread of COVID-19 in Germany: Early assessment and possible scenarios, PLoS ONE 15(9): e0238559, preprint in medRxiv (2020)
- MV Barbarossa, J Fuhrmann, J Heidecke, HV Varma, N Castelletti, J Meinke, S Krieg and Th Lippert, A first study on the impact of current and future control measures on the spread of COVID-19 in Germany, medRxiv (2020)
- new article accepted! Our work on STAT3 regulation of HIF-1α response in IL-15 primed human NK cells just appeared in Scientific Reports (March 2021)
- ENABLE Cluster will be funded!! An exciting time of research on infection, immune responses, tissue damage and disease is going to start in April 2021
- Interview in ProLoewe Persoenlich (03/2021)
- Our work about COVID in the media - here an overview
- Press release on Germany's COVID-19 Lockdown light (Nov 2020)
- Keynote speaker at BIOMAT 2020
- Interview 9 Fragen an Maria Barbarossa
- Farkas Gyula Memorial Award 2018
- Second funding period (2019-2022)!! Scientific Computing for the improved Diagnosis and Therapy of Sepsis (SCIDATOS), funded by the Klaus Tschira Stiftung and jointly realized by the University Medical Centre Mannheim (UMM) and the Interdisciplinary Center for Scientific Computing (IWR)
Mathematical models are used to describe the spread of infectious diseases in a population. Important information can be provided to public health by designing, evaluating and comparing different strategies to control an outbreak.